MOTS-c
Neutral technical record and index of the peer-reviewed literature referencing MOTS-c. For research use only — no human or veterinary use, benefit, or dosing information is provided.
Identity
| PubChem CID | 146675088 |
|---|---|
| CAS number | 1627580-64-6 |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | 2174.6 g/mol |
| InChIKey | WYTHCOXVWRKRAH-LOKRTKBUSA-N |
What it is
MOTS-c is a mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region. It is classed as a mitochondrial-derived signaling peptide. It is supplied as lyophilized material for research use only.
Mechanism (technical)
MOTS-c has been studied for its association with metabolic homeostasis, insulin sensitivity, and glucose metabolism in cell and animal models. Mechanistic work has examined its nuclear translocation and regulation of gene expression under metabolic stress. Its behavior as an exercise-responsive peptide has also been investigated.
Peer-reviewed literature
4 studies indexed · 1 human · 1 animal · 2 in-vitro. Listed neutrally; outcome studies are indexed, not endorsed.
- MOTS-c is an exercise-induced regulator of age-dependent physical decline and muscle homeostasisReynolds JC, et al. · 2021 · Nat Commun · observational · human
- MOTS-c Translocates to the Nucleus to Regulate Gene Expression under Metabolic StressKim KH, et al. · 2018 · Cell Metab · in-vitro · in-vitro
- MOTS-c: a novel mitochondrial-derived peptide regulating muscle and fat metabolismLee C, et al. · 2016 · Free Radic Biol Med · review · in-vitro
- MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistanceLee C, et al. · 2015 · Cell Metab · animal · animal
For research use only. Not for human or veterinary use. Not a drug, food, cosmetic, or dietary supplement. Sold to qualified researchers for laboratory research purposes only.