KPV
Neutral technical record and index of the peer-reviewed literature referencing KPV. For research use only — no human or veterinary use, benefit, or dosing information is provided.
Identity
| PubChem CID | 125672 |
|---|---|
| CAS number | 67727-97-3 |
| Molecular formula | C16H30N4O4 |
| Molecular weight | 342.43 g/mol |
| InChIKey | YSPZCHGIWAQVKQ-AVGNSLFASA-N |
What it is
KPV is a tripeptide (lysine-proline-valine) corresponding to the C-terminal sequence of alpha-melanocyte-stimulating hormone. It is classed as a melanocortin-derived peptide. It is supplied as lyophilized material for research use only.
Mechanism (technical)
KPV has been studied for its association with anti-inflammatory signaling, with in-vitro work examining a role for the melanocortin 3 receptor and studies noting PepT1-mediated cellular uptake. These mechanisms have been investigated in models of intestinal and epithelial inflammation. The molecular pathways remain under study.
Peer-reviewed literature
5 studies indexed · 4 animal · 1 in-vitro. Listed neutrally; outcome studies are indexed, not endorsed.
- Hydrogel-stabilized KPV for TNBS-induced ulcerative colitis in ratsSun J, et al. · 2021 · ACS Biomater Sci Eng · animal · animal
- Orally targeted KPV nanoparticles alleviate ulcerative colitisXiao B, et al. · 2017 · Mol Ther · animal · animal
- PepT1-mediated KPV in a murine model of colitis-associated cancerViennois E, et al. · 2016 · Cell Mol Gastroenterol Hepatol · animal · animal
- KPV inhibits inflammation in human bronchial epithelial cells; MC3R roleLand SC · 2012 · Int J Physiol Pathophysiol Pharmacol · in-vitro · in-vitro
- KPV has anti-inflammatory potential in murine models of IBDKannengiesser K, et al. · 2008 · Inflamm Bowel Dis · animal · animal
For research use only. Not for human or veterinary use. Not a drug, food, cosmetic, or dietary supplement. Sold to qualified researchers for laboratory research purposes only.