5-amino-1MQ
Neutral technical record and index of the peer-reviewed literature referencing 5-amino-1MQ. For research use only — no human or veterinary use, benefit, or dosing information is provided.
Identity
| PubChem CID | 950107 |
|---|---|
| CAS number | 685079-15-6 |
| Molecular formula | C10H11N2+ |
| Molecular weight | 159.21 g/mol |
| InChIKey | ZMJBCEIHNOWCMC-UHFFFAOYSA-O |
What it is
5-amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule quinolinium compound. It is classed as an inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). It is supplied as lyophilized material for research use only.
Mechanism (technical)
5-amino-1MQ has been studied as a membrane-permeable inhibitor of NNMT, an enzyme that methylates nicotinamide. In preclinical work this mechanism has been investigated for its influence on cellular NAD-related and methylation pathways. Its molecular action on NNMT has also been examined in tumor-associated fibroblast models.
Peer-reviewed literature
4 studies indexed · 4 animal. Listed neutrally; outcome studies are indexed, not endorsed.
- NNMT inhibition mitigates obesity-related metabolic dysfunctionBabula JJ, et al. · 2024 · Diabetes Obes Metab · animal · animal
- NNMT in cancer-associated fibroblasts drives tumor progression; 5-amino-1MQ testedYang M, et al. · 2024 · J Immunother Cancer · animal · animal
- Reduced-calorie diet + NNMT inhibition establishes a distinct microbiome in obese miceDimet-Wiley A, et al. · 2022 · Sci Rep · animal · animal
- Membrane-permeable NNMT inhibitors reverse high-fat-diet obesity in miceNeelakantan H, et al. · 2018 · Biochem Pharmacol · animal · animal
For research use only. Not for human or veterinary use. Not a drug, food, cosmetic, or dietary supplement. Sold to qualified researchers for laboratory research purposes only.