SS-31
Also referenced as: Array
Neutral technical record and index of the peer-reviewed literature referencing SS-31. For research use only — no human or veterinary use, benefit, or dosing information is provided.
Identity
| PubChem CID | 11764719 |
|---|---|
| CAS number | 736992-21-5 |
| Molecular formula | C32H49N9O5 |
| Molecular weight | 639.8 g/mol |
| InChIKey | SFVLTCAESLKEHH-WKAQUBQDSA-N |
What it is
SS-31 (elamipretide) is a synthetic mitochondria-targeting tetrapeptide. It is classed as a cardiolipin-binding peptide that localizes to the inner mitochondrial membrane. It is supplied as lyophilized material for research use only.
Mechanism (technical)
SS-31 has been studied for its binding to cardiolipin in the inner mitochondrial membrane, a mechanism investigated for its association with mitochondrial structure and bioenergetics. This rationale underlies its study in disorders of mitochondrial function. The indexed trials focus on functional and patient-reported endpoints.
Peer-reviewed literature
3 studies indexed · 3 human. Listed neutrally; outcome studies are indexed, not endorsed.
- Elamipretide in Primary Mitochondrial Myopathy: MMPOWER-3 RCTKaraa A, et al. · 2023 · Neurology · RCT · human
- Randomized crossover trial of elamipretide in primary mitochondrial myopathy (MMPOWER-2)Karaa A, et al. · 2020 · J Cachexia Sarcopenia Muscle · RCT · human
- Randomized dose-escalation trial of elamipretide in primary mitochondrial myopathyKaraa A, et al. · 2018 · Neurology · RCT · human
For research use only. Not for human or veterinary use. Not a drug, food, cosmetic, or dietary supplement. Sold to qualified researchers for laboratory research purposes only.