Semax
Neutral technical record and index of the peer-reviewed literature referencing Semax. For research use only — no human or veterinary use, benefit, or dosing information is provided.
Identity
| PubChem CID | 9811102 |
|---|---|
| CAS number | 80714-61-0 |
| Molecular formula | C37H51N9O10S |
| Molecular weight | 813.9 g/mol |
| InChIKey | AFEHBIGDWIGTEH-AQRCPPRCSA-N |
What it is
Semax is a synthetic heptapeptide derived from a fragment of adrenocorticotropic hormone with an added stabilizing sequence. It is classed as a melanocortin-related neuropeptide. It is supplied as lyophilized material for research use only.
Mechanism (technical)
Semax has been studied for its association with neuroprotective and neurotrophic signaling in models of cerebral ischemia, with proteomic analyses characterizing changes in brain protein expression. In-vitro work has examined its interaction with copper-induced amyloid-beta aggregation. Effects on hippocampal gene expression under stress have also been investigated.
Peer-reviewed literature
5 studies indexed · 2 human · 2 animal · 1 in-vitro. Listed neutrally; outcome studies are indexed, not endorsed.
- Semax affects copper-induced Abeta aggregation in membrane modelsSciacca MFM, et al. · 2022 · ACS Chem Neurosci · in-vitro · in-vitro
- Brain protein profile confirms protective effect of Semax in rat ischemia-reperfusionSudarkina OY, et al. · 2021 · Int J Mol Sci · animal · animal
- Antistress action of melanocortin derivatives incl. Semax in rat hippocampusFilippenkov IB, et al. · 2021 · Int J Mol Sci · animal · animal
- Efficacy of semax in patients at different stages of ischemic strokeGusev EI, et al. · 2018 · Zh Nevrol Psikhiatr · clinical trial · human
- Effectiveness of semax in acute hemispheric ischemic strokeGusev EI, et al. · 1997 · Zh Nevrol Psikhiatr · clinical trial · human
For research use only. Not for human or veterinary use. Not a drug, food, cosmetic, or dietary supplement. Sold to qualified researchers for laboratory research purposes only.