CJC-1295
Also referenced as: Array
Neutral technical record and index of the peer-reviewed literature referencing CJC-1295. For research use only — no human or veterinary use, benefit, or dosing information is provided.
Identity
| PubChem CID | 91971820 |
|---|---|
| CAS number | 446262-90-4 |
| Molecular formula | C165H269N47O46 |
| Molecular weight | 3647.2 g/mol |
| InChIKey | ZUQGTWKGESAQCD-ZGFIGYLBSA-N |
What it is
CJC-1295 is a synthetic analogue of growth hormone-releasing hormone (GHRH). It belongs to the class of GHRH analogues, and some forms incorporate a drug-affinity complex (DAC) to extend half-life. It is supplied as lyophilized material for research use only.
Mechanism (technical)
CJC-1295 has been studied for its action on GHRH receptors in the pituitary, where it has been investigated for stimulation of endogenous growth hormone secretion and downstream serum IGF-1. Clinical pharmacology studies have characterized the growth hormone secretory pattern and pharmacokinetics under sustained stimulation. A preclinical model examined the growth hormone axis in GHRH-knockout mice.
Peer-reviewed literature
4 studies indexed · 3 human · 1 animal. Listed neutrally; outcome studies are indexed, not endorsed.
- Activation of GH/IGF-1 axis by CJC-1295 changes serum protein profileSackmann-Sala L, et al. · 2009 · Growth Horm IGF Res · clinical trial · human
- Once-daily CJC-1295 normalizes growth in GHRH-knockout miceAlba M, et al. · 2006 · Am J Physiol Endocrinol Metab · animal · animal
- Prolonged stimulation of GH and IGF-I by CJC-1295 in healthy adultsTeichman SL, et al. · 2006 · J Clin Endocrinol Metab · RCT · human
- Pulsatile GH secretion persists during continuous stimulation by CJC-1295Ionescu M, Frohman LA · 2006 · J Clin Endocrinol Metab · clinical trial · human
For research use only. Not for human or veterinary use. Not a drug, food, cosmetic, or dietary supplement. Sold to qualified researchers for laboratory research purposes only.