ARA-290
Also referenced as: Array
Neutral technical record and index of the peer-reviewed literature referencing ARA-290. For research use only — no human or veterinary use, benefit, or dosing information is provided.
Identity
| PubChem CID | 91810664 |
|---|---|
| CAS number | 1208243-50-8 |
| Molecular formula | C51H84N16O21 |
| Molecular weight | 1257.3 g/mol |
| InChIKey | WZTIQQBMSJTRBR-WYKNNRPVSA-N |
What it is
ARA-290 (cibinetide) is a synthetic peptide derived from a non-erythropoietic region of erythropoietin. It belongs to the class of innate repair receptor peptides. It is supplied as lyophilized material for research use only.
Mechanism (technical)
ARA-290 has been studied for its action on the innate repair receptor, a heteromer of the erythropoietin receptor and the beta-common receptor, which does not engage the erythropoietic signaling of classical erythropoietin. This mechanism has been investigated in the context of tissue and nerve-associated signaling. The indexed reviews describe this rationale as the basis for its study.
Peer-reviewed literature
5 studies indexed · 5 human. Listed neutrally; outcome studies are indexed, not endorsed.
- Cibinetide improves corneal nerve fiber abundance in sarcoidosis neuropathyCulver DA, et al. · 2017 · Invest Ophthalmol Vis Sci · clinical trial · human
- ARA 290 improves metabolic control and neuropathic symptoms in type 2 diabetesBrines M, et al. · 2015 · Mol Med · clinical trial · human
- ARA 290 for small fiber neuropathy in sarcoidosis (review)van Velzen M, et al. · 2014 · Expert Opin Investig Drugs · review · human
- ARA 290 improves symptoms and increases corneal nerve fiber density in sarcoidosisDahan A, et al. · 2013 · Mol Med · clinical trial · human
- ARA 290 in sarcoidosis small fiber neuropathy: randomized pilotHeij L, et al. · 2012 · Mol Med · RCT · human
For research use only. Not for human or veterinary use. Not a drug, food, cosmetic, or dietary supplement. Sold to qualified researchers for laboratory research purposes only.